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KMID : 0362919930110020311
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Journal of the Korean Society for Therapeutic Radiology and Oncology
1993 Volume.11 No. 2 p.311 ~ p.319
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Local Control and Survival in Radiation Treatment of Locally Advanced Non-Small Cell Lung Cancer
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Song Mi-Hee
Yang Jin-Yeung
Oh Won-Young
Yoo Nam-Soo
Whang In-Soon
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Abstract
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The retrospective analysis was performed on 37 patients with stage Ⅲ non small cell lung cancer who received the radiotherapy from Feb. 1986 to Dec. 1990 at the Dept. of Radiation Oncology, National Medical Center. This analysis, with 29 patients (78.4%) having been followed from 10 to 60 months, was done to know the survival rate and significant prognostic factor.
The actuarial 2, 5-year survival rates were 20.6%, 6.9% in our all patients and Median survival time was 10 months. Of patients with KPS(Karnofsky performance status) greater than 80%, the 2, 5 year survival rate and median survival time were 29.2%, 9.7% and 13 months, respectively. The 2-year survival rate and median survival time of patients with KPS less than 80% were 13.7% and 7 months, respectively. The survival difference according to performance status was statistically significant(29.2% vs. 13.7%)(p<0.05). In stage Ⅲa, the 2, 5-year survival rate and median survival rate and median survival time were 29.2%, 9.7% and 12 months, respectively. The 2-year survival rate and metian survival time of stage Ⅲb were 8.6% and 10 months, respectively. The survival difference between stage Ⅲa and Ⅲb did not show statistical significance(p>0.1).
Of the prognostic factors, the difference of survival rate by initial performance status was statistically significant (p<0.05). But the difference of survival rates by pathologic cell type, stage, total radiation dose, radiotherapy response, and combination with chemotherapy were not statistically significant.
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KEYWORD
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Radiation Therapy, Locally advanced non small cell lung cancer
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